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Heparin, Buy Heparin Online
Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).
Heparin is a member of the medication groups known as anticoagulants. A question appears: which is the function of an anticoagulant? The action of anticoagulants is keeping from coagulation; in other words, anticoagulant stops blood from clotting. But anticoagulant can't diminish the size of the blood clots which have been already developed. It is necessary to notice that this drug has other functions too. The main purpose of this drug is to fight against invading bacteria and other foreign substances.
This product is administrated by injection into a vein or under the skin (subcutaneously). It must not be injected into a muscle.
Structure of Heparin
Heparin is composed of a variably sulfated repeating disaccharide unit. The most common disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, it makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The main sugars that occur in this medicine are enumerated below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
The sugars enumerated above are present in decreasing amounts, as a regular in the order (2) > (1) > (4) > (3) > (5). This medicine is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups.
Mechanism of action of heparin
It has been already mentioned that heparin stops blood from clotting. How does it work? It neutralizes thrombin. In order to neutralize thrombin this product links itself to the coagulation enzyme and antithrobin. The activated antithrombin neutralizes thrombin and other proteases caused blood clotting. Thus, wee see that antithrombin suppresses coagulation by neutralizing proteins that participate in the coagulation cascade.
Administration of Heparin
Heparin is administrated in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
This product is used to treat persons with following illnesses:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.
Heparin dosage
The prescribed dose of heparin depends on some factors. The dosage is based on the coagulation test results. These tests must be performed very often. The determination of coagulation time henges on some factors. When this drug is administrated by continous intravenous infusion, the coagulation tests should be performed approximately each four hours in the early stages of treatment. When the medication is utilized periodically by intravenous injection, coagulation tests are to be performed before each injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis usual the recommended dosage is 5000 units under the skin every 8 to 12 hours.
Usual dosage for anticoagulation during pregnancy is 5000 units under the skin every 12 hours.
Usual adult dosage for thrombotic disorder is100 units/mL every 6 to 8 hours for PVC catheters and peripheral heparin locks. But when stagnant blood is observed in catheter after it was used for drug or blood administration, it is necessary to add flushes. The dose for babies that have thrombotic disorder is 10 units each 6 to 8 hours. Child dosage in case mentioned above is 100 units/mL every 6 to 8 hours. Additional flushes should be given when stagnant blood is noticed in catheter, after catheter is used for medication or blood administration.
If a person suffers of a massive pulmonary embolism, the initial dose may be an IV bolus of 10,000 units which are followed by 1500 units per hour.
Probable side reactions of heparin
Heparin, as each medicine may lead to adverse consequences. Many patients utilizing heparin do not have got severe unwanted reactions. Some common negative symptoms of this medicine are following: swelling at injection site, bone pain, easily broken bones. Ache and loss of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin may cause some other unwanted symptoms: signs of serious bleeding, including unusual pain, swelling, discomfort, long-term bleeding from cuts, persistent nosebleeds, unusually heavy and long-term menstrual periods, unusual easy damages, dark urine, black stools, serious headache, unusual dizziness.
Severe allergic reactions were reported rarely, but sometimes they can occur. If you utilize this preparation and notice such consequences as rash, itching, swelling, serious dizziness, difficult breathing and others, consult your doctor.
There are such side effects which are caused in case of long-term Heparin administration; others can be results of a systematic administration of this medicine. For example, osteoporosis may be caused by long-term utilizing of high doses of this drug, cutaneous necrosis has been reported after systemic administration; inhibition of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on ceasing of this medication have also been reported.
Important increasing of aminotransferase grades have occurred in a high percentage of patients and healthy people who have received heparin.
Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are used to treat such diseases as embolism and thrombosis. However they sound similar, coumadin and heparin have got many differences. As for using them, coumadin is taken orally, heparin is usedin a form of injection. Coumadin should not be used by pregnant women, heparin can be administrated by pregnant women. Coumadin and heparin can cause excessive bleeding which can be life-threatening.
Heparin recall
Firstly, let notice what medication recalls are. Medicine recalls are such actions which are taken in order to remove some drugs from the market.
As for Heparin, the most of recalls were in 2008 as a result of negative reactions of heparin which was manufactured in China.
But there were no any recalls related to heparin which was prodused by B. Braun Medical Inc. B.Braun manufacturer advices to discontinue heparin utilizing and call your pharmacist, if any negative effects are noticed.
Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia which was caused by utilizing of heparin. Thus, it is a undesirable effect that was caused by heparin administration. There are two types of heparin-induced thrombocytopenia: type 1 and type 2. HIT type 2 is a more serious adverse effect than HIT type 2. HIT type 2 may be a fatal factor. In order to confirm that a patient has HIT, he must do certain laboratory tests.
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